The U.S Postal Service is consolidating four mail processing and distribution centers, including the one in Lafayette.
The USPS is moving all mail operations there to Indianapolis in an effort to cut costs.
Postal Service officials say the system is operating with a deficit due to overpayment to retirement accounts and increased costs.
The mail volume has dropped by about 25-percent over the past six years.
Four of the centers tapped for consolidation will cease all mail operations. Lafayette and three others only will move mail processing, but continue to offer retail operations and Business Mail Entry Units.
Officials say only action by Congress could prevent some or all of the consolidations.